Vang-like protein 2 and Rac1 interact to regulate adherens junctions
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چکیده
منابع مشابه
Vang-like protein 2 and Rac1 interact to regulate adherens junctions.
The Wnt planar cell polarity (Wnt/PCP) pathway signals through small Rho-like GTPases to regulate the cytoskeleton. The core PCP proteins have been mapped to the Wnt/PCP pathway genetically, but the molecular mechanism of their action remains unknown. Here, we investigate the function of the mammalian PCP protein Vang-like protein 2 (Vangl2). RNAi knockdown of Vangl2 impaired cell-cell adhesion...
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How did genetic analysis get started in this system? Here we depended on a breakthrough from the lab of Peter Wolk and Jeff Elhai at Michigan State. They showed that DNA could be transferred by conjugation from E. coli to Anabaena. Postdoc Bill Buikema first isolated mutants incapable of fixing nitrogen, most of which could not differentiate heterocysts. He then used a cosmid library of wild-ty...
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Proper epithelial structure requires adherens junction (AJ) assembly. In the early Drosophila embryo, AJ assembly depends on Bazooka (Baz; PAR-3), but it is unclear how Baz affects AJ assembly and what precursors are involved. To understand this process at the molecular level, we counted the number of core AJ proteins and Baz proteins at an average spot AJ (SAJ) and determined their dynamics wi...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2010
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.048074